Aplysamine 6, an alkaloidal inhibitor of isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.

被引：38

作者：

Buchanan, Malcolm S. ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Fechner, Gregory A. ^{[1
]}

Boyle, Anthony ^{[1
]}

Simpson, Moana ^{[1
]}

Addepalli, Rama ^{[1
]}

Avery, Vicky M. ^{[1
]}

Hooper, John N. A. ^{[2
]}

Cheung, Tony ^{[3
]}

Chen, Huwei ^{[3
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Queensland Museum, Queensland Ctr Biodivers, Brisbane, Qld 4101, Australia

[3] AstraZeneca R&D Boston, Waltham, MA 02451 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np0706623

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an a,p-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by ID and 2D NMR spectroscopy.

引用

页码：1066 / 1067

页数：2

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