Anti-viral cyclam macrocycles: rapid zinc uptake at physiological pH

被引：64

作者：

Paisey, SJ ^{[1
]}

Sadler, PJ ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 03期

关键词：

D O I：

10.1039/b312752b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR and UV-vis spectroscopic studies show that Zn(II) binds to cyclam rapidly at micromolar concentrations, an observation relevant to the anti-viral activity and co-receptor binding of anti-HIV cyclams.

引用

页码：306 / 307

页数：2

共 17 条

[1] STRUCTURE OF A COMPLEX OF 1,4,8,11-TETRAAZACYCLOTETRADECANE (CYCLAM) WITH ZINC(II) CHLORIDE [J].

ALCOCK, NW ;

BERRY, A ;

MOORE, P .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1992, 48 :16-19

[2] The bicyclam AMD3 100 story [J].

De Clercq, E .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (07) :581-587

[3] POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-1 AND HIV-2 REPLICATION BY A CLASS OF BICYCLAMS INTERACTING WITH A VIRAL UNCOATING EVENT [J].

DECLERCO, E ;

YAMAMOTO, N ;

PAUWELS, R ;

BABA, M ;

SCHOLS, D ;

NAKASHIMA, H ;

BALZARINI, J ;

DEBYSER, Z ;

MURRER, BA ;

SCHWARTZ, D ;

THORNTON, D ;

BRIDGER, G ;

FRICKER, S ;

HENSON, G ;

ABRAMS, M ;

PICKER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5286-5290

[4] Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor [J].

Esté, JA ;

Cabrera, C ;

De Clercq, E ;

Struyf, S ;

Van Damme, J ;

Bridger, G ;

Skerlj, RT ;

Abrams, MJ ;

Henson, G ;

Gutierrez, A ;

Clotet, B ;

Schols, D .

MOLECULAR PHARMACOLOGY, 1999, 55 (01) :67-73

[5] Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers [J].

Hendrix, CW ;

Flexner, C ;

MacFarland, RT ;

Giandomenico, C ;

Fuchs, EJ ;

Redpath, E ;

Bridger, G ;

Henson, GW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1667-1673

[6] COMPLEXES WITH MACROCYCLIC LIGANDS .1. MECHANISM OF COMPLEX FORMATION BETWEEN NI2+ AND 1,4,8,11-TETRAAZACYCLOTETRADECANE [J].

KADEN, T .

HELVETICA CHIMICA ACTA, 1970, 53 (03) :617-&

[7] Design of potent selective zinc-mediated serine protease inhibitors [J].

Katz, BA ;

Clark, JM ;

Finer-Moore, JS ;

Jenkins, TE ;

Johnson, CR ;

Ross, MJ ;

Luong, C ;

Moore, WR ;

Stroud, RM .

NATURE, 1998, 391 (6667) :608-612

[8] MACROCYCLIC POLYAMINES WITH INTELLIGENT FUNCTIONS [J].

KIMURA, E .

TETRAHEDRON, 1992, 48 (30) :6175-6217

[9] EQUILIBRIA AND KINETICS OF COMPLEX-FORMATION BETWEEN ZINC(II), LEAD(II), AND CADMIUM(II), AND 12-MEMBERED, 13-MEMBERED, 14-MEMBERED AND 15-MEMBERED MACROCYCLIC TETRA-AMINES [J].

KODAMA, M ;

KIMURA, E .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1977, (22) :2269-2276

[10] KINETIC AND EQUILIBRIUM STUDIES ON COPPER(II) COMPLEXES OF A 9-MEMBERED MACROCYCLIC TRIAMINE, 1,4,7-TRIAZACYCLONONANE, AND A 14-MEMBERED MACROCYCLIC TETRA-AMINE, 1,4,8,11-TETRA-AZACYCLOTETRADECANE [J].

KODAMA, M ;

KIMURA, E .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1977, (15) :1473-1478

← 1 2 →