Monodispersed, molecularly imprinted polymers as affinity-based chromatography media

被引：136

作者：

Haginaka, Jun ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 866卷 / 1-2期

关键词：

molecularly imprinted polymer; monodispersed MIP; MIP microsphere; affinity-based media; pharmaceutical analysis; environmental analysis; bioanalysis;

D O I：

10.1016/j.jchromb.2007.07.019

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This review article deals with preparation methods for spherical and monodispersed molecularly imprinted polymers (MIPs) in micrometer sizes. Those methods include suspension polymerization in water, liquid perfluorocarbon and mineral oil, seed polymerization and dispersion/precipitation polymerization. The other methods are the use of beaded materials such as a spherical silica or organic polymer for grafting MIP phases onto the surfaces of porous materials or filling the pores of silica with MIPs followed by dissolution of the silica. Furthermore, applications of MIP microspheres as affinity-based chromatography media, HPLC stationary phases and solid-phase extraction media, will be discussed for pharmaceutical, biomedical and environmental analysis. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：3 / 13

页数：11

共 95 条

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[Anonymous], 2001, MOL IMPRINTED POLYM

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