Heart rate informed artificial pancreas system enhances glycemic control during exercise in adolescents with T1D

Objective: To evaluate the safety and performance of using a heart rate (HR) monitor to inform an artificial pancreas (AP) system during exercise among adolescents with type 1 diabetes (T1D). Materials and Methods: In a randomized, cross-over trial, adolescents with T1D age 1318 years were enrolled to receive on separate days either the unmodified UVa AP (stdAP) or an AP system connected to a portable HR monitor (AP-HR) that triggered an exercise algorithm for blood glucose (BG) control. During admissions participants underwent a structured exercise regimen. Hypoglycemic events and CGM tracings were compared between the two admissions, during exercise and for the full 24-hour period. Results: Eighteen participants completed the trial. While number of hypoglycemic events during exercise and rest was not different between visits (0.39 AP-HR vs 0.50 stdAP), time below 70 mg dL(-1) was lower on AP-HR compared to stdAP, 0.5 +/- 2.1% vs 7.4 +/- 12.5% (P = 0.028). Time with BG within 70-180 mg dL(-1) was higher for the AP-HR admission vs stdAP during the exercise portion and overall (96% vs 87%, and 77% vs 74%), but these did not reach statistical significance (P = 0.075 and P = 0.366). Conclusions: Heart rate signals can safely and efficaciously be integrated in a wireless AP system to inform of physical activity. While exercise contributes to hypoglycemia among adolescents, even when using an AP system, informing the system of exercise via a HR monitor improved time < 70 mg dL(-1). Nonetheless, it did not significantly reduce the total number of hypoglycemic events, which were low in both groups.