An efficient FeCl3-catalyzed amidation reaction of secondary benzylic and allylic alcohols with carboxamides or p-toluenesulfonamide

被引：116

作者：

Jana, Umasish ^{[1
]}

Maiti, Sukhendu ^{[1
]}

Biswas, Srijit ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 05期

关键词：

ferric chloride; amidation reactions; alcohols; atom-economical; inexpensive;

D O I：

10.1016/j.tetlet.2007.11.176

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, inexpensive, environmentally friendly and high yielding amidation reaction of benzylic and allylic alcohols with primary amides using a catalytic amount of FeCl3 (5 mol %) is described. Direct substitution of various amides such as benzamide, sulfonamide, acetamide and acrylamide is reported, and this method also works on a large scale in high yield. (C) 2007 Elsevier Ltd. All rights reserved.

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页码：858 / 862

页数：5

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