Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?

被引：129

作者：

Lan, Qin ^{[1
,2
]}

Fan, Huimin ^{[2
]}

Quesniaux, Valerie ^{[3
,4
]}

Ryffel, Bernhard ^{[3
,4
]}

Liu, Zhongmin ^{[2
]}

Zheng, Song Guo ^{[1
,3
,4
]}

机构：

[1] Univ So Calif, Div Rheumatol & Immunol, Dept Med, Keck Sch Med, Los Angeles, CA 90033 USA

[2] Tongji Univ, Shanghai E Hosp, Med Translat Ctr, Shanghai 200120, Peoples R China

[3] Univ Orleans, UMR6218, F-45071 Orleans, France

[4] CNRS, F-45071 Orleans, France

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2012年 / 4卷 / 01期

基金：

中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

autoimmune and inflammatory diseases; immunoregulation; regulatory T cells; TGF-beta; Foxp3; Th17; cells; atRA; GENERATED EX-VIVO; LUPUS-PRONE MICE; TGF-BETA; CUTTING EDGE; IN-VIVO; SUPPRESS; EXPRESSION; INDUCTION; CD4(+); IL-2;

D O I：

10.1093/jmcb/mjr039

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Foxp3(+) T regulatory cells (Tregs) consisting of natural and induced Treg subsets play a crucial role in the maintenance of immune homeostasis against self-antigen. The actions designed to correct defects in numbers or functions of Tregs may be therapeutic in the treatment of autoimmune diseases. While recent studies demonstrated that natural Tregs are instable and dysfunctional in the inflammatory condition, induced Tregs (iTregs) may have a different feature. Here we review the progress of iTregs, particularly focus on their stability and function in the established autoimmune diseases. The advantage of iTregs as therapeutics used under inflammatory conditions is highlighted. Proper generation and manipulation of iTregs used for cellular therapy may provide a promise for the treatment of many autoimmune and inflammatory diseases.

引用

页码：22 / 28

页数：7

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