A practical approach for preparation of 2-[(dialkylamino)-methyl]-4-aryl-2H-phthalazin-1-ones via Mannich reaction of 4-aryl-2H-phthalazin-1-ones

被引：7

作者：

Epsztajn, J ^{[1
]}

Malinowski, Z

Urbaniak, P

Andrijewski, G

机构：

[1] Univ Lodz, Inst Chem, Dept Organ Chem, Lodz, Poland

[2] Univ Lodz, Inst Chem, Dept Gen & Inorgan Chem, Lodz, Poland

来源：

SYNTHETIC COMMUNICATIONS | 2005年 / 35卷 / 02期

关键词：

metal complexes; heterocycles; organometalic compounds; Mannich bases; tautomerism;

D O I：

10.1081/SCC-200048404

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 4-aryl-2H-phthalazin-1-ones 5 and their successive conversion, via the Mannich reaction into 2-[(dialkylamino)-methyl]-4-aryl-2H-phthalazin-1-ones 6, 7, 8, 9 as a way of regiospecific transformation of the 4-methoxybenzanilide 1, is described. In addition, the compounds 5b and 7 appeared to be effective complexing ligands for such metal as Cu(II), Ni(II), Fe(II), and Fe(III).

引用

收藏

页码：179 / 192

页数：14

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