Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method -: art. no. 68

被引:105
作者
Eerikäinen, H
Peltonen, L
Raula, J
Hirvonen, J
Kauppinen, EI
机构
[1] Aalto Univ, Ctr New Mat, FIN-02044 Espoo, Finland
[2] Univ Helsinki, Fac Pharm, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, Viikki Drug Discovery Ctr, FIN-00014 Helsinki, Finland
[4] VTT Proc, Aerosol Technol Grp, FIN-02044 Espoo, Finland
关键词
nanoparticles; ketoprofen; aerosol; polymer; Eudragit;
D O I
10.1208/pt050468
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.
引用
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页数:9
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