Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain

被引：150

作者：

Licastro, F

Grimaldi, LME

Bonafè, M

Martina, C

Olivieri, F

Cavallone, L

Giovanietti, S

Masliah, E

Franceschi, C

机构：

[1] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[2] Dept Neurosci, Caltanisetta, Italy

[3] INRCA Res Dept, Ancona, Italy

[4] Univ Calif San Diego, Dept Neurosci & Pathol, San Diego, CA 92103 USA

来源：

NEUROBIOLOGY OF AGING | 2003年 / 24卷 / 07期

关键词：

Alzheimer's disease risk; IL-6; gene; blood and brain IL-6 levels;

D O I：

10.1016/S0197-4580(03)00013-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The - 174 C allele in the promoter region of IL-6 gene was over-represented in AD patients compared to controls and significantly increased the risk of AD. Moreover, the - 174 CC genotype was associated with a high risk of the disease in women. The D allele of a variable number of tandem repeat (VNTR) was in strong linkage disequilibrium with the - 174 C allele and slightly increased AD risk. On the other hand, the frequency of the VNTR C allele was decreased in patients with AD and was negatively associated with the risk of developing AD. Both the - 174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：921 / 926

页数：6

共 39 条

[31] GLIAL CYTOKINES IN ALZHEIMERS-DISEASE - REVIEW AND PATHOGENIC IMPLICATIONS [J].