Special cells, special considerations: The challenges of bringing embryonic stem cells from the laboratory to the clinic

被引：11

作者：

Addis, R. C. ^{[1
,2
]}

Bulte, J. W. M. ^{[3
,4
,5
]}

Gearhart, J. D. ^{[1
,2
,6
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Stem Cell Biol Program, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Mckusick Nathans Inst Genet Med, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Cellular Imaging Sect & Vasc Biol Program, Inst Cell Engn, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Div MR Res, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[5] Johns Hopkins Univ, Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2008年 / 83卷 / 03期

关键词：

D O I：

10.1038/sj.clpt.6100384

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Human embryonic stem (ES) cells are an attractive tool for cell-based therapies because of their limitless capacity for proliferation and their ability to differentiate into all cell types of the body. However, these features introduce certain unique risks that must be considered in developing transplantation strategies for clinical use. We outline these risks and examine current approaches to address them, both before and after transplantation.

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收藏

页码：386 / 389

页数：4

相关论文

共 27 条

[1] Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats [J].

Buehnemann, Claudia ;

Scholz, Andreas ;

Bernreuther, Christian ;

Malik, Christoph Y. ;

Braun, Holger ;

Schachner, Melitta ;

Reymann, Klaus G. ;

Dihne, Marcel .

BRAIN, 2006, 129 :3238-3248

[2] Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells [J].

Bulte, JWM ;

Douglas, T ;

Witwer, B ;

Zhang, SC ;

Strable, E ;

Lewis, BK ;

Zywicke, H ;

Miller, B ;

van Gelderen, P ;

Moskowitz, BM ;

Duncan, ID ;

Frank, JA .

NATURE BIOTECHNOLOGY, 2001, 19 (12) :1141-1147

[3] Hot spot MRI emerges from the background [J].

Bulte, JWM .

NATURE BIOTECHNOLOGY, 2005, 23 (08) :945-946

[4] Iron oxide MR contrast agents for molecular and cellular imaging [J].

Bulte, JWM ;

Kraitchman, DL .

NMR IN BIOMEDICINE, 2004, 17 (07) :484-499

[5] Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation [J].

Cao, Feng ;

Drukker, Micha ;

Lin, Shuan ;

Sheikh, Ahmad Y. ;

Xie, Xiaoyan ;

Li, Zongjin ;

Connolly, Andrew J. ;

Weissman, Irving L. ;

Wu, Joseph C. .

CLONING AND STEM CELLS, 2007, 9 (01) :107-117

[6] Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy [J].

de Vries, IJM ;

Lesterhuis, WJ ;

Barentsz, JO ;

Verdijk, P ;

van Krieken, JH ;

Boerman, OC ;

Oyen, WJG ;

Bonenkamp, JJ ;

Boezeman, JB ;

Adema, GJ ;

Bulte, JWM ;

Scheenen, TWJ ;

Punt, CJA ;

Heerschap, A ;

Figdor, CG .

NATURE BIOTECHNOLOGY, 2005, 23 (11) :1407-1413

[7]

GAO F, 2007, NMR BIOMED

[8] Artificial reporter gene providing MRI contrast based on proton exchange [J].

Gilad, Assaf A. ;

McMahon, Michael T. ;

Walczak, Piotr ;

Winnard, Paul T., Jr. ;

Raman, Venu ;

van Laarhoven, Hanneke W. M. ;

Skoglund, Cynthia M. ;

Bulte, Jeff W. M. ;

van Zijl, Peter C. M. .

NATURE BIOTECHNOLOGY, 2007, 25 (02) :217-219

[9] In vivo magnetic resonance imaging of single cells in mouse brain with optical validation [J].

Heyn, C ;

Ronald, JA ;

Mackenzie, LT ;

MacDonald, IC ;

Chambers, AF ;

Rutt, BK ;

Foster, PJ .

MAGNETIC RESONANCE IN MEDICINE, 2006, 55 (01) :23-29

[10] Monitoring of implanted stem cell migration in vivo:: A highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat [J].

Hoehn, M ;

Küstermann, E ;

Blunk, J ;

Wiedermann, D ;

Trapp, T ;

Wecker, S ;

Föcking, M ;

Arnold, H ;

Hescheler, J ;

Fleischmann, BK ;

Schwindt, W ;

Bührle, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) :16267-16272