The AT2 receptor - A matter of love and hate

被引：214

作者：

Steckelings, UM ^{[1
]}

Kaschina, E ^{[1
]}

Unger, T ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Inst Pharmacol & Toxicol, Cardiovasc Res Ctr, D-10115 Berlin, Germany

来源：

PEPTIDES | 2005年 / 26卷 / 08期

关键词：

angiotensin; AT2; receptor; renin-angiotensin-system;

D O I：

10.1016/j.peptides.2005.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 1989, the development of specific angiotensin receptor antagonists which distinguish between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in angiotensin research. It turned out, that the AT I receptor was almost entirely responsible for the "classical" actions of angiotensin II related to the regulation of blood pressure as well as volume and electrolyte balance. However, actions and signal transduction mechanisms coupled to the AT2 receptor remained enigmatic for a long time. The present review surnmarizes the current knowledge of AT2 receptor distribution, signaling and function with an emphasis on growth/anti-growth, differentiation and the regeneration of neuronal tissue. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1401 / 1409

页数：9

共 108 条

[11] Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease [J].

Bullock, GR ;

Steyaert, I ;

Bilbe, G ;

Carey, RM ;

Kips, J ;

De Paepe, B ;

Pauwels, R ;

Praet, M ;

Siragy, HM ;

de Gasparo, M .

HISTOCHEMISTRY AND CELL BIOLOGY, 2001, 115 (02) :117-124

[12] Expression of angiotensin AT1 and AT2 receptors in adult rat cardiomyocytes after myocardial infarction -: A single-cell reverse transcriptase-polymerase chain reaction study [J].

Busche, S ;

Gallinat, S ;

Bohle, RM ;

Reinecke, A ;

Seebeck, J ;

Franke, F ;

Fink, L ;

Zhu, MY ;

Sumners, C ;

Unger, T .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (02) :605-611

[13] Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function [J].

Carey, RM ;

Wang, ZQ ;

Siragy, HM .

HYPERTENSION, 2000, 35 (01) :155-163

[14] IDENTIFICATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES [J].

CHIU, AT ;

HERBLIN, WF ;

MCCALL, DE ;

ARDECKY, RJ ;

CARINI, DJ ;

DUNCIA, JV ;

PEASE, LJ ;

WONG, PC ;

WEXLER, RR ;

JOHNSON, AL ;

TIMMERMANS, PBMWM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) :196-203

[15] Nitric oxide, a new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells. [J].

Côté, F ;

Laflamme, L ;

Payet, MD ;

Gallo-Payet, N .

ENDOCRINE RESEARCH, 1998, 24 (3-4) :403-407

[16] Activation of the AT2 receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum [J].

Côté, F ;

Do, TH ;

Laflamme, L ;

Gallo, JM ;

Gallo-Payet, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (44) :31686-31692

[17] The renin-angiotensin system in the brain: an update [J].

Culman, J ;

Baulmann, J ;

Blume, A ;

Unger, T .

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2001, 2 (02) :96-102

[18] Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):: a randomised trial against atenolol [J].

Dahlöf, B ;

Devereux, RB ;

Kjeldsen, SE ;

Julius, S ;

Beevers, G ;

de Faire, U ;

Fyhrquist, F ;

Ibsen, H ;

Kristiansson, K ;

Lederballe-Pedersen, O ;

Lindholm, LH ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wedel, H .

LANCET, 2002, 359 (9311) :995-1003

[19] Blockade of central angiotensin AT1 receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats [J].

Dai, WJ ;

Funk, A ;

Herdegen, T ;

Unger, T ;

Culman, J .

STROKE, 1999, 30 (11) :2391-2398

[20]

de Gasparo M, 2000, PHARMACOL REV, V52, P415

← 1 2 3 4 5 6 7 8 9 10 →