The AT2 receptor - A matter of love and hate

被引：214

作者：

Steckelings, UM ^{[1
]}

Kaschina, E ^{[1
]}

Unger, T ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Inst Pharmacol & Toxicol, Cardiovasc Res Ctr, D-10115 Berlin, Germany

来源：

PEPTIDES | 2005年 / 26卷 / 08期

关键词：

angiotensin; AT2; receptor; renin-angiotensin-system;

D O I：

10.1016/j.peptides.2005.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 1989, the development of specific angiotensin receptor antagonists which distinguish between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in angiotensin research. It turned out, that the AT I receptor was almost entirely responsible for the "classical" actions of angiotensin II related to the regulation of blood pressure as well as volume and electrolyte balance. However, actions and signal transduction mechanisms coupled to the AT2 receptor remained enigmatic for a long time. The present review surnmarizes the current knowledge of AT2 receptor distribution, signaling and function with an emphasis on growth/anti-growth, differentiation and the regeneration of neuronal tissue. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1401 / 1409

页数：9

共 108 条

[61]

Lonchampt M, 2001, INVEST OPHTH VIS SCI, V42, P429

[62] The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats [J].

Lucius, R ;

Gallinat, S ;

Rosenstiel, P ;

Herdegen, T ;

Sievers, J ;

Unger, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (04) :661-670

[63]

Luther C, 2000, HYPERTENSION, V36, P655

[64] Transient upregulation of the AT2 receptor mRNA level after global ischemia in the rat brain [J].

Makino, I ;

Shibata, K ;

Ohgami, Y ;

Fujiwara, M ;

Furukawa, T .

NEUROPEPTIDES, 1996, 30 (06) :596-601

[65] Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridization [J].

Matsubara, H ;

Sugaya, T ;

Murasawa, S ;

Nozawa, Y ;

Mori, Y ;

Masaki, H ;

Maruyama, K ;

Tsutumi, Y ;

Shibasaki, Y ;

Moriguchi, Y ;

Tanaka, Y ;

Iwasaka, T ;

Inada, M .

NEPHRON, 1998, 80 (01) :25-34

[66] DIFFERENTIAL GENE-EXPRESSION AND REGULATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN RAT CARDIAC FIBROBLASTS AND CARDIOMYOCYTES IN CULTURE [J].

MATSUBARA, H ;

KANASAKI, M ;

MURASAWA, S ;

TSUKAGUCHI, Y ;

NIO, Y ;

INADA, M .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04) :1592-1601

[67] The angiotensin II AT(2) receptor inhibits proliferation and promotes differentiation in PC12W cells [J].

Meffert, S ;

Stoll, M ;

Steckelings, UM ;

Bottari, SP ;

Unger, T .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1996, 122 (01) :59-67

[68] Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis [J].

Miura, SI ;

Karnik, SS .

EMBO JOURNAL, 2000, 19 (15) :4026-4035

[69] Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney [J].

Miyata, N ;

Park, F ;

Li, XF ;

Cowley, AW .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1999, 277 (03) :F437-F446

[70] Opposing actions of angiotensin II on microvascular growth and arterial blood pressure [J].

Munzenmaier, DH ;

Greene, AS .

HYPERTENSION, 1996, 27 (03) :760-765

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