Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes

被引：80

作者：

Ahn, Jiyun ^{[1
]}

Lee, Hyunjung ^{[1
]}

Kim, Suna ^{[1
]}

Ha, Taeyoul ^{[1
]}

机构：

[1] Korea Food Res Inst, Food Funct Res Grp, Songnam 463746, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 364卷 / 04期

关键词：

resveratrol; 3T3-L1; adipocyte; PAI-1; adiponectin; IL-6;

D O I：

10.1016/j.bbrc.2007.10.109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-alpha are implicated in the induction of atherogenic adipokines, such as plasminogen activator inhibitor 4 (PAI-1) and IL-6, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of resveratrol on TNF-alpha-induced atherogenic changes of the adipokines in 3T3-L1 cells. Exposure to TNF-alpha for 24 h increased PAI-1 and IL-6 secretion and decreased adiponectin secretion. The mRNA expression of adipokines changed in parallel with mRNA expression. Resveratrol effectively reversed the secretion and mRNA expression of the atherogenic adipokines, PAI-1 and IL-6, induced by TNF-alpha. Decreased secretion levels and mRNA expression of adiponectin by TNF-alpha were also recovered by resveratrol treatment. Our results suggest that resveratrol may improve obesity-induced cardiovascular disease, particularly atherosclerosis, by attenuating the TNF-alpha-induced changes of adipokines. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：972 / 977

页数：6

共 42 条

[41] The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity [J].

Yamauchi, T ;

Kamon, J ;

Waki, H ;

Terauchi, Y ;

Kubota, N ;

Hara, K ;

Mori, Y ;

Ide, T ;

Murakami, K ;

Tsuboyama-Kasaoka, N ;

Ezaki, O ;

Akanuma, Y ;

Gavrilova, O ;

Vinson, C ;

Reitman, ML ;

Kagechika, H ;

Shudo, K ;

Yoda, M ;

Nakano, Y ;

Tobe, K ;

Nagai, R ;

Kimura, S ;

Tomita, M ;

Froguel, P ;

Kadowaki, T .

NATURE MEDICINE, 2001, 7 (08) :941-946

[42] Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase [J].

Yeung, F ;

Hoberg, JE ;

Ramsey, CS ;

Keller, MD ;

Jones, DR ;

Frye, RA ;

Mayo, MW .

EMBO JOURNAL, 2004, 23 (12) :2369-2380

← 1 2 3 4 5 →