One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

被引：50

作者：

Barber, David M. ^{[1
]}

Sanganee, Hitesh ^{[2
]}

Dixon, Darren J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 15期

基金：

英国工程与自然科学研究理事会;

关键词：

AZA-HENRY REACTION; N-TOSYL IMINES; MANNICH REACTIONS; TRANSITION-METAL; ASYMMETRIC HYDROAMINATION; ORGANIC-SYNTHESIS; ATOM ECONOMY; ALKYNES; AMINES; DERIVATIVES;

D O I：

10.1039/c1cc10751h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(III) catalysis is reported.

引用

页码：4379 / 4381

页数：3

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