Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method

被引：18

作者：

Hayakawa, Y ^{[1
]}

Hirata, A ^{[1
]}

Sugimoto, J ^{[1
]}

Kawai, R ^{[1
]}

Sakakura, A ^{[1
]}

Kataoka, M ^{[1
]}

机构：

[1] Nagoya Univ, Bioorgan Chem Lab, Grad Sch Human Informat, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON | 2001年 / 57卷 / 42期

基金：

日本学术振兴会;

关键词：

nucleotides; molecular sieves; phosphoramidites;

D O I：

10.1016/S0040-4020(01)00880-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It is demonstrated that the reaction of a nucleoside phosphoramidite and a nucleoside aided by a suitable promoter in the presence of molecular sieves 3A or 4A in a liquid phase is efficiently performed by the use of stoichiometric amounts of the reactants to give the desired coupling product in an excellent yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：8823 / 8826

页数：4

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