Synthesis of Aryl Fluorides on a Solid Support and in Solution by Utilizing a Fluorinated Solvent

被引：76

作者：

Doebele, Marion ^{[1
]}

Vanderheiden, Sylvia ^{[1
,2
]}

Jung, Nicole ^{[1
,2
]}

Braese, Stefan ^{[1
,2
]}

机构：

[1] Inst Organ Chem, D-76131 Karlsruhe, Germany

[2] IOC ComPlat, D-76344 Eggenstein Leopoldshafen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 34期

关键词：

Balz-Schiemann reaction; combinatorial chemistry; perfluorinated solvents; solid-phase synthesis; triazenes; ARENEDIAZONIUM IONS; 2,4,6-TRIMETHYLBENZENEDIAZONIUM ION; HOMOGENEOUS SOLUTION; AROMATIC FLUORIDES; DEDIAZONIATION; DECOMPOSITION; 1-ARYL-3,3-DIALKYLTRIAZENES; BENZENEDIAZONIUM; SALTS; ACIDS;

D O I：

10.1002/anie.201001507

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) F for fast: The perfluorinated solvent C 6F14 is the key to a new variant of the BalzSchiemann reaction for the synthesis of fluorinated arenes. Triazenes are converted into fluoroarenes under mild con-ditions on a support and in solution (see scheme). The method is straightforward and inexpensive, and yields previously difficult-to-prepare fluoroarenes in high purity. © 2010 wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5986 / 5988

页数：3

共 39 条

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