Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

被引：2326

作者：

Galliford, Chris V. ^{[1
]}

Scheidt, Karl A. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60201 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 46期

关键词：

antitumor agents; medicinal chemistry; natural products; spirooxindoles; total synthesis;

D O I：

10.1002/anie.200701342

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：8748 / 8758

页数：11

共 158 条

[81] Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays [J].

Kuruvilla, FG ;

Shamji, AF ;

Sternson, SM ;

Hergenrother, PJ ;

Schreiber, SL .

NATURE, 2002, 416 (6881) :653-657

[82] Total synthesis of (-)-horsfiline via asymmetric nitroolefination [J].

Lakshmaiah, G ;

Kawabata, T ;

Shang, MH ;

Fuji, K .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (05) :1699-1704

[83] First total synthesis of (±)-strychnofoline via a highly selective ring-expansion reaction [J].

Lerchner, A ;

Carreira, EM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (50) :14826-14827

[84]

Lerchner A, 2006, CHEM-EUR J, V12, P8209

[85]

Liu G, 2006, PROG CHEM, V18, P734

[86] Development and applications of topologically segregated bilayer beads in one-bead one-compound combinatorial libraries [J].

Liu, RW ;

Wang, XB ;

Song, AM ;

Bao, T ;

Lam, KS .

QSAR & COMBINATORIAL SCIENCE, 2005, 24 (10) :1127-1140

[87] A library of spirooxindoles based on a stereoselective three-component coupling reaction [J].

Lo, MMC ;

Neumann, CS ;

Nagayama, S ;

Perlstein, EO ;

Schreiber, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) :16077-16086

[88]

Madin A, 1999, ANGEW CHEM INT EDIT, V38, P2934

[89]

Madin A., 1999, ANGEW CHEM, V111, P3110

[90] Enantiocontrolled synthesis of spirooxindoles based on the [5+2] cycloaddition of a Tp(CO)2Mo(pyridinyl) scaffold (Tp = hydridotrispyrazolylborate) [J].

Malinakova, HC ;

Liebeskind, LS .

ORGANIC LETTERS, 2000, 2 (25) :4083-4086

← 4 5 6 7 8 9 10 11 12 13 →