Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

被引：1136

作者：

Bissell, Mina J. ^{[1
]}

Hines, William C. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

NATURE MEDICINE | 2011年 / 17卷 / 03期

关键词：

ROUS-SARCOMA-VIRUS; HUMAN BREAST CELLS; TUMOR-GROWTH; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; 3-DIMENSIONAL CULTURE; STROMAL FIBROBLASTS; TISSUE ARCHITECTURE; STIMULATING FACTOR; OCCULT CARCINOMA;

D O I：

10.1038/nm.2328

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.

引用

页码：320 / 329

页数：10

共 145 条

[81] Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion [J].

Orimo, A ;

Gupta, PB ;

Sgroi, DC ;

Arenzana-Seisdedos, F ;

Delaunay, T ;

Naeem, R ;

Carey, VJ ;

Richardson, AL ;

Weinberg, RA .

CELL, 2005, 121 (03) :335-348

[82]

Paget S., 1989, Cancer Metastas-.-. Rev., V8, P98

[83] Cysteine cathepsin proteases as pharmacological targets in cancer [J].

Palermo, Carmela ;

Joyce, Johanna A. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2008, 29 (01) :22-28

[84] MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor [J].

Pan, Bo-Sheng ;

Chan, Grace K. Y. ;

Chenard, Melissa ;

Chi, An ;

Davis, Lenora J. ;

Deshmukh, Sujal V. ;

Gibbs, Jackson B. ;

Gil, Susana ;

Hang, Gaozhen ;

Hatch, Harold ;

Jewell, James P. ;

Kariv, Ilona ;

Katz, Jason D. ;

Kunii, Kaiko ;

Lu, Wei ;

Lutterbach, Bart A. ;

Paweletz, Cloud P. ;

Qu, Xianlu ;

Reilly, John F. ;

Szewczak, Alexander A. ;

Zeng, Qinwen ;

Kohl, Nancy E. ;

Dinsmore, Christopher J. .

CANCER RESEARCH, 2010, 70 (04) :1524-1533

[85] β1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts [J].

Park, Catherine C. ;

Zhang, Hui J. ;

Yao, Evelyn S. ;

Park, Chong J. ;

Bissell, Mina J. .

CANCER RESEARCH, 2008, 68 (11) :4398-4405

[86] β1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo [J].

Park, CC ;

Zhang, H ;

Paravicini, M ;

Gray, JW ;

Baehner, F ;

Park, CJ ;

Bissell, MJ .

CANCER RESEARCH, 2006, 66 (03) :1526-1535

[87]

PATEL J, 1981, CANCER-AM CANCER SOC, V47, P2923, DOI 10.1002/1097-0142(19810615)47:12<2923::AID-CNCR2820471231>3.0.CO

[88]

2-N

[89] Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer [J].

Paulsson, Janna ;

Sjoblom, Tobias ;

Micke, Patrick ;

Ponten, Fredrik ;

Landberg, Goran ;

Heldin, Carl-Henrik ;

Bergh, Jonas ;

Brennan, Donal J. ;

Jirstrom, Karin ;

Ostman, Arne .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (01) :334-341

[90] The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts [J].

Peinado, Hector ;

Lavotshkin, Simon ;

Lyden, David .

SEMINARS IN CANCER BIOLOGY, 2011, 21 (02) :139-146

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