The clinical potential of chemokine receptor antagonists

被引：100

作者：

Ribeiro, S

Horuk, R

机构：

[1] Berlex Biosci, Dept Immunol, Richmond, CA 94804 USA

[2] Berlex Biosci, Dept Mol Pharmacol, Richmond, CA 94804 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2005年 / 107卷 / 01期

关键词：

chemokine; G-protein coupled receptor; receptor antagonists; autoimmune diseased; multiple sclerosis; clinical trials;

D O I：

10.1016/j.pharmthera.2005.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemokines belong to a family of chemotactic cytokines that direct the migration of immune cells towards sites of inflammation. They mediate their biological effects by binding to cell surface receptors, which belong to the G protein-coupled receptor superfamily. Since chemokines and their receptors have been implicated in the pathophysiology of a number of autoinflammatory diseases, chemokine receptor antagonists could prove to be useful therapeutics to target these diseases. Here, we review the role of chemokines in autoimmunity, concentrating mainly on the chemokine receptors CCR1 and CCR5, and discuss the potential utility of antagonists that target these 2 receptors as they progress through the clinic. (c) 2005 Published by Elsevier Inc.

引用

页码：44 / 58

页数：15

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