Enantioselective copper-catalyzed propargylic amination

被引：202

作者：

Detz, Remko J. ^{[1
]}

Delville, Marielle M. E. ^{[1
]}

Hiemstra, Henk ^{[1
]}

van Maarseveen, Jan H. ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci Biomol Synth, NL-1018 WS Amsterdam, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期

关键词：

amination; asymmetric catalysis; P; N ligands; propargylic amines; pybox ligands;

D O I：

10.1002/anie.200705264

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A proper copper catalyst with a chiral pyridine-2,6-bisoxazoline (pybox) ligand was used to convert a variety of propargylic acetates with aromatic side chains (R = Ar) into their amine counterparts in high yield and with good selectivity (up to 88% ee). The resulting chiral propargylic amines can be elaborated further into P,N ligands (see scheme; DIPEA = diisopropylethylamine). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3777 / 3780

页数：4

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