Rhodium-catalyzed propargylic substitution: A divergent approach to propargylic and allenyl sulfonamides

被引：29

作者：

Evans, P. Andrew ^{[1
]}

Lawler, Michael J. ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 30期

关键词：

allenes; carbocyclization; isomerization; rhodium; sulfonamides;

D O I：

10.1002/anie.200600615

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Construction work: Rh-catalyzed propargylic amination provides an efficient, versatile method for the preparation of aliphatic propargylic sulfonamides. This Rh-catalyzed variant has a divergent nature, from which aryl-substituted propargylic and allenyl sulfonamides can be constructed. A one-pot two-component Rh-catalyzed propargylic amination/isomerization followed by a [4+2] carbocy-carbocyclization demonstrates the synthetic utility of this divergent behavior. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：4970 / 4972

页数：3

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