Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

被引：34

作者：

Bailly, Fabrice ^{[1
]}

Queffelec, Clemence ^{[1
]}

Mbemba, Gladys ^{[2
]}

Mouscadet, Jean-Francois ^{[2
]}

Pommery, Nicole ^{[3
]}

Pommery, Jean ^{[3
]}

Henichart, Jean-Pierre ^{[3
]}

Cotelle, Philippe ^{[1
]}

机构：

[1] Univ Lille 1, Lab Chim Organ & Macromol, CNRS, UMR 8009, F-59655 Villeneuve Dascq, France

[2] ENS, CNRS, UMR 8113, Lab Biotechnol & Pharmacol Genet Appl, F-94235 Cachan, France

[3] Inst Chim Pharmaceut Albert Lespagnol, EA 2692, F-59006 Lille, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 06期

关键词：

3-hydroxy-2-(5H)-furanones; antioxidant; 5-lipoxygenase; cyclooxygenases; HIV-1; integrase; PC3; proliferation;

D O I：

10.1016/j.ejmech.2007.08.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test. (c) 2007 Elsevier Masson SAS. All rights reserved.

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收藏

页码：1222 / 1229

页数：8

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