Phenanthridinium cyclobisintercalands. Fluorescence sensing of AMP and selective binding to single-stranded nucleic acids

被引：45

作者：

Piantanida, I

Palm, BS

Cudic, P

Zinic, M ^{[1
]}

Schneider, HJ

机构：

[1] Univ Saarland, FR Organ Chem, D-66041 Saarbrucken, Germany

[2] Rudjer Boskovic Inst, Div Chem & Biochem, Lab Supramol & Nucleoside Chem, HR-10000 Zagreb, Croatia

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(01)01386-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrocyclic ligands 1 and 2 containing two positively charged phenanthridinium units and aminobisacetylenic bridges, exhibit significantly higher affinity toward single-stranded rather than double-stranded polynucleotides. The ligands bis-intercalate into the former and show non-intercalative interactions with the latter type of nucleic acids. Both ligands differentiate AMP from the GMP or UMP by significant fluorescence emission increase upon complexation of the first nucleotide in water (log KS of 1:1 and 1:2 complexes 5.8 and 1.4, respectively), while only a slight emission change is observed in titrations with GMP and UMP. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6779 / 6783

页数：5

共 31 条

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