Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: Pharmacological, phylogenetic, and drug discovery aspects

被引：47

作者：

Costanzi, Stefano ^{[2
]}

Neumann, Susanne ^{[1
]}

Gershengorn, Marvin C. ^{[1
]}

机构：

[1] NIDDK, Clin Endocrinol Branch, NIH, Bethesda, MD 20892 USA

[2] NIDDK, Lab Biol Modeling, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 24期

关键词：

D O I：

10.1074/jbc.R800014200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：16269 / 16273

页数：5

共 39 条

[21] A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs [J].

Kotarsky, K ;

Nilsson, NE ;

Flodgren, E ;

Owman, C ;

Olde, B .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (02) :406-410

[22] GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo [J].

Latour, Martin G. ;

Alquier, Thierry ;

Oseid, Elizabeth ;

Tremblay, Caroline ;

Jetton, Thomas L. ;

Luo, Jian ;

Lin, Daniel C. -H. ;

Poitout, Vincent .

DIABETES, 2007, 56 (04) :1087-1094

[23] G protein-coupled receptors and insulin secretion: 119 and counting [J].

Madiraju, S. R. Murthy ;

Poitout, Vincent .

ENDOCRINOLOGY, 2007, 148 (06) :2598-2600

[24] Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor [J].

McKeown, Stephen C. ;

Corbett, David F. ;

Goetz, Aaron S. ;

Littleton, Thomas R. ;

Bigham, Eric ;

Briscoe, Celia P. ;

Peat, Andrew J. ;

Watson, Steve P. ;

Hickey, Deirdre M. B. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (06) :1584-1589

[25] G protein-coupled receptors for free fatty acids [J].

Milligan, Graeme ;

Stoddart, Leigh A. ;

Brown, Andrew J. .

CELLULAR SIGNALLING, 2006, 18 (09) :1360-1365

[26] GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity [J].

Overton, H. A. ;

Fyfe, M. C. T. ;

Reynet, C. .

BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 :S76-S81

[27] Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents [J].

Overton, HA ;

Babbs, AJ ;

Doel, SM ;

Fyfe, MCT ;

Gardner, LS ;

Griffin, G ;

Jackson, HC ;

Procter, MJ ;

Rasamison, CM ;

Tang-Christensen, M ;

Widdowson, PS ;

Williams, GM ;

Reynet, C .

CELL METABOLISM, 2006, 3 (03) :167-175

[28] Fatty acid receptors as new therapeutic targets for diabetes [J].

Rayasam, Geetha Vani ;

Tulasi, Vamshi Krishna ;

Davis, Joseph Alex ;

Bansal, Vinay S. .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (05) :661-671

[29] Role of GPR40 in fatty acid action on the β cell line INS-1E [J].

Shapiro, H ;

Shachar, S ;

Sekler, I ;

Hershfinkel, M ;

Walker, MD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 335 (01) :97-104

[30] Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor [J].

Soga, T ;

Ohishi, T ;

Matsui, T ;

Saito, T ;

Matsumoto, M ;

Takasaki, J ;

Matsumoto, S ;

Kamohara, M ;

Hiyama, H ;

Yoshida, S ;

Momose, K ;

Ueda, Y ;

Matsushime, H ;

Kobori, M ;

Furuichi, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 326 (04) :744-751

← 1 2 3 4 →