DNA Origami: The Art of Folding DNA

被引：297

作者：

Sacca, Barbara ^{[1
]}

Niemeyer, Christof M. ^{[1
]}

机构：

[1] Tech Univ Dortmund, Fak Chem, D-44227 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 01期

关键词：

design; DNA origami; DNA sequence design; nanostructures; self-assembly; supramolecuar chemistry; DIRECTED NUCLEATION; SHAPES; TILES; NANOSTRUCTURES; NANOPARTICLES; DESIGN; GROWTH;

D O I：

10.1002/anie.201105846

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The advent of DNA origami technology greatly simplified the design and construction of nanometer-sized DNA objects. The self-assembly of a DNA-origami structure is a straightforward process in which a long single-stranded scaffold (often from the phage M13mp18) is folded into basically any desired shape with the help of a multitude of short helper strands. This approach enables the ready generation of objects with an addressable surface area of a few thousand nm2 and with a single pixel resolution of about 6 nm. The process is rapid, puts low demands on experimental conditions, and delivers target products in high yields. These features make DNA origami the method of choice in structural DNA nanotechnology when two- and three-dimensional objects are desired. This Minireview summarizes recent advances in the design of DNA origami nanostructures, which open the door to numerous exciting applications.

引用

页码：58 / 66

页数：9

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