Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street

被引：141

作者：

Barrett, David M. ^{[1
]}

Grupp, Stephan A. ^{[1
,2
]}

June, Carl H. ^{[2
,3
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pediat, Div Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF IMMUNOLOGY | 2015年 / 195卷 / 03期

关键词：

CYTOKINE RELEASE SYNDROME; ADOPTIVE TRANSFER; SIGNAL-TRANSDUCTION; REGULATORY CELLS; CANCER-IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; MEMORY; THERAPY; MOUSE; CD28;

D O I：

10.4049/jimmunol.1500751

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The field of adoptive cell transfer (ACT) is currently comprised of chimeric Ag receptor (CAR)- and TCR-engineered T cells and has emerged from principles of basic immunology to paradigm-shifting clinical immunotherapy. ACT of T cells engineered to express artificial receptors that target cells of choice is an exciting new approach for cancer, and it holds equal promise for chronic infection and autoimmunity. Using principles of synthetic biology, advances in immunology, and genetic engineering have made it possible to generate human T cells that display desired specificities and enhanced functionalities. Clinical trials in patients with advanced B cell leukemias and lymphomas treated with CD19-specific CAR T cells have induced durable remissions in adults and children. The prospects for the widespread availability of engineered T cells have changed dramatically given the recent entry of the pharmaceutical industry to this arena. In this overview, we discuss some of the challenges and opportunities that face the field of ACT.

引用

页码：755 / 761

页数：7

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