Simultaneous determination of four components in composite vitamin B tablets using a square-root Kalman filter

A square-root Kalman filter combined with spectrometry has been applied to determining the concentrations of vitamin B-1, vitamin B-2, vitamin B-6 and nicotinamide in synthetic mixtures and in a commercial composite vitamin B tablet. A simultaneous assay of the components in synthetic mixtures containing the above mentioned four B-complex vitamins was successfully achieved with satisfactory recoveries of 97.0 - 103.3%. The components in a commercial composite vitamin B tablet were determined simultaneously, and the obtained results are in good agreement with the labeled contents of the tablet.