The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

被引：228

作者：

Dolmetsch, Ricardo ^{[1
]}

Geschwind, Daniel H. ^{[2
,3
,4
]}

机构：

[1] Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA

[2] UCLA Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[3] UCLA Sch Med, Dept Psychiat, Los Angeles, CA 90095 USA

[4] UCLA Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

CELL | 2011年 / 145卷 / 06期

关键词：

PLURIPOTENT STEM-CELLS; SCHIZOPHRENIA;

D O I：

10.1016/j.cell.2011.05.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

引用

页码：831 / 834

页数：4

共 20 条

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