Dendritic cells and viral immunity: friends or foes?

被引：18

作者：

Kaiserlian, D ^{[1
]}

Dubois, B ^{[1
]}

机构：

[1] INSERM U404 Immunite & Vaccinat, IFR 74 Immunol Virol & Pathol Emergentes, F-69365 Lyon 07, France

来源：

SEMINARS IN IMMUNOLOGY | 2001年 / 13卷 / 05期

关键词：

CTL; dendritic cells; immune suppression; pathology; virus infection;

D O I：

10.1006/smim.2001.0326

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) residing in epithelial issues of various mucosae and the skin are characterized by the unique ability to capture antigens and migrate to draining lymph nodes, where they can activate naive a nd memory T cells. Although DC play a pivotal role in inducing protective immunity to viral infection, they can also be exploited by viruses to evade the host immune response, induce immune suppression, or serve as latent viral reservoirs. Thus, virus interactions with DC may lead to an immune response that can be protective, but does not necessarily lead to complete virus elimination, resulting in immunopathology. (C) 2001 Academic Press.

引用

收藏

页码：303 / 310

页数：8

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