Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation

被引：169

作者：

Yasui, Yoshimmi ^{[1
]}

Kamisaki, Haruhi ^{[1
]}

Takemoto, Yoshiji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 15期

关键词：

D O I：

10.1021/ol801168j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective cyanoamidation of olefins provides quick access to a variety of 3,3-disubstituted oxindoles. The combination of Pd(dba)(2), an optically active phosphoramidite, and N,N-dimethylpropylene urea (DMPU) in decalin were found to be the best conditions.

引用

页码：3303 / 3306

页数：4

共 38 条

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