The multifaceted adult epidermal stem cell

被引：83

作者：

Gambardella, L ^{[1
]}

Barrandon, Y

机构：

[1] Swiss Fed Inst Technol, Sch Life Sci, Lab Stem Cell Dynam, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne Hosp, Dept Expt Surg, CH-1015 Lausanne, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2003.10.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adult epidermal stem cells renew the epithelial compartment of the skin throughout life and are the most accessible of all adult stem cells. Most importantly, epidermal stem cells can be efficiently cultivated and transplanted, a significant advantage for cell and gene therapy. Recent work has pointed to the hair follicle as the main repository of multipotent stem cells in skin. Hair follicles, which are often affected in the mouse by spontaneous or man-made mutations, have become superb model systems to study the cellular and molecular factors that regulate the proliferation, migration and fate of adult stem cells.

引用

页码：771 / 777

页数：7

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