Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases

被引：112

作者：

Burton, Oliver T. ^{[1
]}

Oettgen, Hans C. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Div Immunol, Boston, MA 02115 USA

来源：

IMMUNOLOGICAL REVIEWS | 2011年 / 242卷

基金：

美国国家卫生研究院;

关键词：

IgE; allergy; mast cell; FC-EPSILON-RI; MAST-CELL SURVIVAL; DELAYED-TYPE HYPERSENSITIVITY; TUMOR-NECROSIS-FACTOR; SCHISTOSOMA-MANSONI; SERUM IGE; IN-VITRO; BARRIER FUNCTION; IMMUNOGLOBULIN-E; HUMAN BASOPHILS;

D O I：

10.1111/j.1600-065X.2011.01024.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidence from our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, Fc epsilon RI and CD23, as well as controlling mast cell homeostasis. We provide an overview of the multifaceted ways in which IgE antibodies contribute to the pathology of food allergy and speculate regarding potential mechanisms of action of IgE blockade.

引用

页码：128 / 143

页数：16

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