M1/M2 macrophage polarity in normal and complicated pregnancy

被引：169

作者：

Brown, Mary B. ^{[1
]}

von Chamier, Maria ^{[1
]}

Allam, Ayman B. ^{[1
]}

机构：

[1] Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, DH Barron Reprod & Pernatal Biol Res Program, Gainesville, FL 32611 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

关键词：

macrophages; M1/M2; normal pregnancy; complicated pregnancy; uterine atherosis; spiral artery; chorioamnionitis; spontaneous abortion; PORPHYROMONAS-GINGIVALIS INFECTION; PLACENTAL HOFBAUER CELLS; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; DECIDUAL MACROPHAGES; T-CELLS; PHENOTYPIC CHARACTERIZATION; INFLAMMATORY RESPONSE; SPONTANEOUS-ABORTION; INDUCED APOPTOSIS;

D O I：

10.3389/fimmu.2014.00606

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue macrophages play an important role in all stages of pregnancy, including uterine stromal remodeling (decidualization) before embryo implantation, parturition, and post-partum uterine involution. The activation state and function of utero-placental macrophages are largely dependent on the local tissue microenvironment. Thus, macrophages are involved in a variety of activities such as regulation of immune cell activities, placental cell invasion, angiogenesis, and tissue remodeling. Disruption of the uterine microenvironment, particularly during the early stages of pregnancy (decidualization, implantation, and placentation) can have profound effects on macrophage activity and subsequently impact pregnancy outcome. In this review, we will provide an overview of the temporal and spatial regulation of utero-placental macrophage activation during normal pregnancy in human beings and rodents with a focus on more recent findings. We will also discuss the role of M 1/M2 dysregulation within the intrauterine environment during adverse pregnancy outcomes.

引用

页数：10

共 115 条

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