Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus

被引：6

作者：

Kim, YS

Liu, QX

Chow, LL

Chambers, HF

Täuber, MG

机构：

[1] San Francisco Gen Hosp, Infect Dis Lab, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 12期

关键词：

D O I：

10.1128/AAC.42.12.3325

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than van; comycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) or ampicillin-sulbactam plus rifampin (4.9 +/- 1.1 CFU/g). The addition of ampicillin-sulbactam to trovafloxacin tended to reduce titers further.

引用

收藏

页码：3325 / 3327

页数：3

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