A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

被引：44

作者：

Bekker, PJ

Holloway, DL

Rasmussen, AS

Murphy, R

Martin, SW

Leese, PT

Holmes, GB

Dunstan, CR

DePaoli, AM

机构：

[1] Amgen Inc, Newbury Pk, CA 91320 USA

[2] Quintiles, Lenexa, KS USA

[3] SFBC Int Inc, Miami, FL USA

[4] ANZAC Res Inst, Concord, NSW, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 12期

关键词：

RANKL; osteoprotegerin; osteoporosis; bone resorption; AMG; 162;

D O I：

10.1359/jbmr.2005.20.12.2274

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The safety and bone antiresorptive effect of a single subcutaneous dose of AMG 162, a human monoclonal antibody to RANKL, was investigated in 49 postmenopausal women. AMG 162 is a potent antiresorptive agent for diseases such as osteoporosis.

引用

页码：2274 / 2282

页数：9

共 50 条

[41] RANK ligand and osteoprotegerin in myeloma bone disease [J].

Sezer, O ;

Heider, U ;

Zavrski, I ;

Kühne, CA ;

Hofbauer, LC .

BLOOD, 2003, 101 (06) :2094-2098

[42] Osteoprotegerin: A novel secreted protein involved in the regulation of bone density [J].

Simonet, WS ;

Lacey, DL ;

Dunstan, CR ;

Kelley, M ;

Chang, MS ;

Luthy, R ;

Nguyen, HQ ;

Wooden, S ;

Bennett, L ;

Boone, T ;

Shimamoto, G ;

DeRose, M ;

Elliott, R ;

Colombero, A ;

Tan, HL ;

Trail, G ;

Sullivan, J ;

Davy, E ;

Bucay, N ;

RenshawGegg, L ;

Hughes, TM ;

Hill, D ;

Pattison, W ;

Campbell, P ;

Sander, S ;

Van, G ;

Tarpley, J ;

Derby, P ;

Lee, R ;

Boyle, WJ .

CELL, 1997, 89 (02) :309-319

[43] Mutation screening of the TNFRSF11A gene encoding receptor activator of NFκB (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma [J].

Sparks, AB ;

Peterson, SN ;

Bell, C ;

Loftus, BJ ;

Hocking, L ;

Cahill, DP ;

Frassica, FJ ;

Streeten, EA ;

Levine, MA ;

Fraser, CM ;

Adams, MD ;

Broder, S ;

Venter, JC ;

Kinzler, KW ;

Vogelstein, B ;

Ralston, SH .

CALCIFIED TISSUE INTERNATIONAL, 2001, 68 (03) :151-155

[44] Breast cancer cells interact with osteoblasts to support osteoclast formation [J].

Thomas, RJ ;

Guise, TA ;

Yin, JJ ;

Elliott, J ;

Horwood, NJ ;

Martin, TJ ;

Gillespie, MT .

ENDOCRINOLOGY, 1999, 140 (10) :4451-4458

[45] Skeletal benefits of alendronate: 7-year treatment of postmenopausal osteoporotic women [J].

Tonino, RP ;

Meunier, PJ ;

Emkey, R ;

Rodriguez-Portales, JA ;

Menkes, CJ ;

Wasnich, RD ;

Bone, HG ;

Santora, AC ;

Wu, M ;

Desai, R ;

Ross, PD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (09) :3109-3115

[46] Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis [J].

Tsuda, E ;

Goto, M ;

Mochizuki, S ;

Yano, K ;

Kobayashi, F ;

Morinaga, T ;

Higashio, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 234 (01) :137-142

[47] Osteoprotegerin deficiency and juvenile Paget's disease [J].

Whyte, MP ;

Obrecht, SE ;

Finnegan, PM ;

Jones, JL ;

Podgornik, MN ;

McAlister, WH ;

Mumm, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (03) :175-184

[48] Identification and characterization of a new member of the TNF family that induces apoptosis [J].

Wiley, SR ;

Schooley, K ;

Smolak, PJ ;

Din, WS ;

Huang, CP ;

Nicholl, JK ;

Sutherland, GR ;

Smith, TD ;

Rauch, C ;

Smith, CA ;

Goodwin, RG .

IMMUNITY, 1995, 3 (06) :673-682

[49] Osteoclast differentiation factor is a ligand for osteoprotegerin osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL [J].

Yasuda, H ;

Shima, N ;

Nakagawa, N ;

Yamaguchi, K ;

Kinosaki, M ;

Mochizuki, S ;

Tomoyasu, A ;

Yano, K ;

Goto, M ;

Murakami, A ;

Tsuda, E ;

Morinaga, T ;

Higashio, K ;

Udagawa, N ;

Takahashi, N ;

Suda, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3597-3602

[50] Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone [J].

Zhang, J ;

Dai, JL ;

Qi, YH ;

Lin, DL ;

Smith, P ;

Strayhorn, C ;

Mizokami, A ;

Fu, Z ;

Westman, J ;

Keller, ET .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (10) :1235-1244

← 1 2 3 4 5 →