Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens

被引：49

作者：

Chukwujekwu, JC

Smith, P

Coombes, PH

Mulholland, DA

van Staden, J

机构：

[1] Univ KwaZulu Natal Pietermaritzburg, Res Ctr Plant Growth & Dev, Sch Biol & Conservat Sci, ZA-3209 Scottsdale, South Africa

[2] Univ KwaZulu Natal, Sch Chem, ZA-4041 Durban, South Africa

[3] Univ Cape Town, Dept Med, Div Pharmacol, ZA-7925 Cape Town, South Africa

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 102卷 / 02期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

diterpenoid; Hyptis suaveolens; 13 alpha-epi-dioxiabiet-8(14)en-18-ol; leaf extracts; Malaria;

D O I：

10.1016/j.jep.2005.08.018

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-guided fractionation of the petroleum ether extract of the leaves of Hyptis suaveolens, widely used in Traditional Medicine, has led to the isolation of an abietane-type diterpenoid endoperoxide, 13 alpha-epi-dioxiabiet-8(14)-en-18-ol, displaying high antiplasmodial activity (IC50 0.1 mu g/ml). (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：295 / 297

页数：3

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