Synthesis and radioprotective study of new siladithioacetals and germadithioacetals

被引：5

作者：

Célariès, B

Amourette, C

Lion, C

Rima, G

机构：

[1] Univ Toulouse 3, CNRS, UMR 5069, Lab Heterochim Fondamentale & Appl, F-31062 Toulouse 4, France

[2] Ctr Rech Serv Sante Armees, F-38702 La Tronche, France

[3] Univ Paris 07, CNRS, ITODYS, F-75005 Paris, France

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2003年 / 17卷 / 08期

关键词：

siladithioacetals; germadithioacetals; toxicity; LD50; naphthylethylimidazoline; radioprotective activity;

D O I：

10.1002/aoc.472

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and their radiopharmacological properties (radioprotective activity and toxicity) have been determined in mice. A number of these new organometallic derivatives have been found to possess radioprotective activity. We have also noted a notable decrease of the toxicity and a fairly large increase in the radioprotective activity in comparison with the unsubstituted organic molecules. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：561 / 569

页数：9

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