Enantioselective synthesis of (-)-cis-clavicipitic acid

被引：46

作者：

Ku, Jin-Mo

Jeong, Byeong-Seon

Jew, Sang-sup ^{[1
]}

Park, Hyeung-geun

机构：

[1] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 21期

关键词：

D O I：

10.1021/jo071162h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An enantioselective synthetic method for (-)-cis-clavicipitic acid (1) was reported. 1 was obtained in 10 steps (99% ee and 20% overall yield) from 1H-indole-3-carboxylic acid methyl ester (9) via asymmetric phase-transfer catalytic alkylation and diastereoselective Pd(II)-catalyzed intramolecular aminocyclization as key steps.

引用

收藏

页码：8115 / 8118

页数：4

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