Biomedical applications of cyclodextrin based polyrotaxanes

被引：142

作者：

Loethen, Scott ^{[1
]}

Kim, Jong-Mok ^{[1
]}

Thompson, David H. ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

POLYMER REVIEWS | 2007年 / 47卷 / 03期

关键词：

cyclodextrin; drug delivery; hydrogel; polyrotaxane; polypseudorotaxane; pseudopolyrotaxane;

D O I：

10.1080/15583720701455145

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Due to their controllable size, low cytotoxicity, and unique architecture, cyclodextrin-based polyrotaxanes and pseudopolyrotaxanes have been developed to encompass a broad range of diverse medical applications from. erodable hydrogels to drug and gene delivery. This review summarizes the synthesis, characterization, dynamics, applications, and potential utility of cyclodextrin based polyrotaxanes and pseudopolyrotaxanes for medical applications. Specifically, this article reviews the literature appearing on this topic between 1999 and November 2006.

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页码：383 / 418

页数：36

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