Synthesis and biological evaluation of gambierol analogues

被引：28

作者：

Fuwa, H

Kainuma, N

Satake, M

Sasaki, M

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

[2] Univ Tokyo, Grad Sch Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(03)00467-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2519 / 2522

页数：4

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