Localization of D-serine and serine racemase in neurons and neuroglias in mouse brain

被引：42

作者：

Ding, Xiaohui ^{[1
]}

Ma, Ning ^{[2
]}

Nagahama, Masato ^{[3
]}

Yamada, Kumiko ^{[3
]}

Semba, Reiji ^{[3
]}

机构：

[1] ShenYang Med Coll, Dept Histol & Embryol, Shenyang 110034, Peoples R China

[2] Suzuka Univ Med Sci, Dept Hlth & Hyg, Matsusaka, Mie, Japan

[3] Mie Univ, Dept Anat, Sch Med, Tsu, Mie 5148507, Japan

来源：

NEUROLOGICAL SCIENCES | 2011年 / 32卷 / 02期

基金：

日本学术振兴会;

关键词：

D-Serine; Serine; Racemase; Neuron; Neuroglia; Mouse; RAT-BRAIN; MESSENGER-RNA;

D O I：

10.1007/s10072-010-0422-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

d-Serine is a novel candidate for an intrinsic ligand for the glycine site of N-methyl-d-aspartate (NMDA) receptors in mammalian brain. d-Serine and serine racemase, which produces d-serine from l-serine, have long been presumed to be localized in astrocytes. However, we have reported that d-serine immunoreactivity was observed in neurons in rats. In the present study, the distributions of d-serine and serine racemase were investigated in combination with marker proteins for neurons, astrocytes and oligodendrocytes in mice. Immunoreactivities for d-serine and serine racemase were found in neurons and oligodendrocytes. These results suggest that d-serine can be produced in neurons as well as glias and used as a neurotransmitter, which control the synaptic function of NMDA receptors.

引用

页码：263 / 267

页数：5

共 20 条

[1]

Human serine racemase: moleular cloning, genomic organization and functional analysis [J].