An update on Middle East respiratory syndrome: 2 years later

被引：16

作者：

Al-Tawfiq, Jaffar A. ^{[1
,2
]}

Memish, Ziad A. ^{[3
,4
]}

机构：

[1] Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia

[2] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[3] Minist Hlth, Riyadh 11176, Saudi Arabia

[4] Alfaisal Univ, Riyadh 11176, Saudi Arabia

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2015年 / 9卷 / 03期

关键词：

coronavirus; MERS-CoV; Middle East respiratory syndrome; SYNDROME CORONAVIRUS INFECTION; RECEPTOR-BINDING DOMAIN; TO-HUMAN TRANSMISSION; HEALTH-CARE WORKER; MERS-CORONAVIRUS; SAUDI-ARABIA; NEUTRALIZING ANTIBODIES; DROMEDARY CAMELS; SPIKE PROTEIN; TRACT INFECTIONS;

D O I：

10.1586/17476348.2015.1027689

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized in 2012 and since then has resulted in cases in 23 countries in four continents. The majority of these cases were reported from the Kingdom of Saudi Arabia. The disease caused a spectrum of illness, from asymptomatic to severe and possibly fatal disease. Recent studies showed that the transmission of MERS-CoV among family contacts remains relatively low. Currently, there are no approved vaccines or therapeutics for MERS-CoV.

引用

页码：327 / 335

页数：9

共 82 条

[31] In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection [J].

Eckerle, Isabella ;

Mueller, Marcel A. ;

Kallies, Stephan ;

Gotthardt, Daniel N. ;

Drosten, Christian .

VIROLOGY JOURNAL, 2013, 10

[32]

Epidemic, MOL EP EV VIR PATH E

[33] Unanswered questions about the Middle East respiratory syndrome coronavirus (MERS-CoV) [J].

Gardner L.M. ;

Macintyre C.R. .

BMC Research Notes, 7 (1)

[34] Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity [J].

Gierer, Stefanie ;

Mueller, Marcel A. ;

Heurich, Adeline ;

Ritz, Daniel ;

Springstein, Benjamin L. ;

Karsten, Christina B. ;

Schendzielorz, Alexander ;

Gnirss, Kerstin ;

Drosten, Christian ;

Poehlmann, Stefan .

JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (06) :889-897

[35] Lack of MERS Coronavirus Neutralizing Antibodies in Humans, Eastern Province, Saudi Arabia [J].

Gierer, Stefanie ;

Hofmann-Winkler, Heike ;

Albuali, Waleed H. ;

Bertram, Stephanie ;

Al-Rubaish, Abdullah M. ;

Yousef, Abdullah A. ;

Al-Nafaie, Awatif N. ;

Al-Ali, Amein K. ;

Obeid, Obeid E. ;

Alkharsah, Khaled R. ;

Poehlmann, Stefan .

EMERGING INFECTIOUS DISEASES, 2013, 19 (12) :2034-2036

[36] The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies [J].

Gierer, Stefanie ;

Bertram, Stephanie ;

Kaup, Franziska ;

Wrensch, Florian ;

Heurich, Adeline ;

Kraemer-Kuehl, Annika ;

Welsch, Kathrin ;

Winkler, Michael ;

Meyer, Benjamin ;

Drosten, Christian ;

Dittmer, Ulf ;

von Hahn, Thomas ;

Simmons, Graham ;

Hofmann, Heike ;

Poehlmann, Stefan .

JOURNAL OF VIROLOGY, 2013, 87 (10) :5502-5511

[37] Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation [J].

Haagmans, Bart L. ;

Al Dhahiry, Said H. S. ;

Reusken, Chantal B. E. M. ;

Raj, V. Stalin ;

Galiano, Monica ;

Myers, Richard ;

Godeke, Gert-Jan ;

Jonges, Marcel ;

Farag, Elmoubasher ;

Diab, Ayman ;

Ghobashy, Hazem ;

Alhajri, Farhoud ;

Al-Thani, Mohamed ;

Al-Marri, Salih A. ;

Al Romaihi, Hamad E. ;

Al Khal, Abdullatif ;

Bermingham, Alison ;

Osterhaus, Albert D. M. E. ;

AlHajri, Mohd M. ;

Koopmans, Marion P. G. .

LANCET INFECTIOUS DISEASES, 2014, 14 (02) :140-145

[38] Health Care Worker Contact with MERS Patient, Saudi Arabia [J].

Hall, Aron J. ;

Tokars, Jerome I. ;

Badreddine, Samar A. ;

Bin Saad, Ziad ;

Furukawa, Elaine ;

Al Masri, Malak ;

Haynes, Lia M. ;

Gerber, Susan I. ;

Kuhar, David T. ;

Miao, Congrong ;

Trivedi, Suvang U. ;

Pallansch, Mark A. ;

Hajjeh, Rana ;

Memish, Ziad A. .

EMERGING INFECTIOUS DISEASES, 2014, 20 (12) :2148-2151

[39]

Hijawi B, 2013, E MEDITERR HEALTH J, V19, pS12

[40] Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen [J].

Lan, Jiaming ;

Deng, Yao ;

Chen, Hong ;

Lu, Guangwen ;

Wang, Wen ;

Guo, Xiaojuan ;

Lu, Zhuozhuang ;

Gao, George F. ;

Tan, Wenjie .

PLOS ONE, 2014, 9 (11)

← 1 2 3 4 5 6 7 8 9 →