Cancer chemopreventive agents.: New depsidones from Garcinia plants

被引:38
作者
Ito, C
Itoigawa, M [1 ]
Mishina, Y
Tomiyasu, H
Litaudon, M
Cosson, JP
Mukainaka, T
Tokuda, H
Nishino, H
Furukawa, H
机构
[1] Tokai Gakuen Univ, Aichi 4700207, Japan
[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan
[3] CNRS, Lab Plantes Med, Noumea, New Caledonia
[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyou Ku, Kyoto 6020841, Japan
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期
关键词
D O I
10.1021/np000333+
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In a search for cancer chemopreventive agents from natural sources, chemical constituents of two kinds of Garcinia plants, Garcinia neglecta and Garcinia puat, collected in New Caledonia, were examined. Five new depsidones, garcinisidone-B (2), -C (3), D (4), -E (5), and -F (6), were isolated, and their structures were determined by spectrometric analyses. Inhibitory effects of these depsidones on EBV-EA activation induced by TPA in Raji cells were also demonstrated.
引用
收藏
页码:147 / 150
页数:4
相关论文
共 12 条
  • [1] *AM SOC PHARM, 1990, 41 ANN M AM SOC PHAR
  • [2] XANTHONES FROM GARCINIA-FORBESII
    HARRISON, LJ
    LEONG, LS
    SIA, GL
    SIM, KY
    TAN, HTW
    [J]. PHYTOCHEMISTRY, 1993, 33 (03) : 727 - 728
  • [3] Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay
    Ito, C
    Itoigawa, M
    Furukawa, H
    Tokuda, H
    Okuda, Y
    Mukainaka, T
    Okuda, M
    Nishino, H
    [J]. CANCER LETTERS, 1999, 138 (1-2) : 87 - 92
  • [4] Chemical constituents of Clausena excavata:: Isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion
    Ito, C
    Itoigawa, M
    Katsuno, S
    Omura, M
    Tokuda, H
    Nishino, H
    Furukawa, H
    [J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (09): : 1218 - 1224
  • [5] Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis
    Ito, C
    Itoigawa, M
    Tan, HTW
    Tokuda, H
    Mou, XY
    Mukainaka, T
    Ishikawa, T
    Nishino, H
    Furukawa, H
    [J]. CANCER LETTERS, 2000, 152 (02) : 187 - 192
  • [6] Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis
    Ito, C
    Itoigawa, M
    Furukawa, H
    Ichiishi, E
    Mukainaka, T
    Okuda, M
    Ogata, M
    Tokuda, H
    Nishino, H
    [J]. CANCER LETTERS, 1999, 142 (01) : 49 - 54
  • [7] New carbazole alkaloids from Clausena anisata with antitumor promoting activity
    Ito, C
    Katsuno, S
    Itoigawa, M
    Ruangrungsi, N
    Mukainaka, T
    Okuda, M
    Kitagawa, Y
    Tokuda, H
    Nishino, H
    Furukawa, H
    [J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01): : 125 - 128
  • [8] Ito C, 1997, CHEM PHARM BULL, V45, P1403, DOI 10.1248/cpb.45.1403
  • [9] Xanthones as inhibitors of Epstein-Barr virus activation
    Ito, C
    Itoigawa, M
    Furukawa, H
    Rao, KS
    Enjo, F
    Bu, P
    Takayasu, J
    Tokuda, H
    Nishino, H
    [J]. CANCER LETTERS, 1998, 132 (1-2) : 113 - 117
  • [10] A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity
    Ito, C
    Itoigawa, M
    Miyamoto, Y
    Rao, KS
    Takayasu, J
    Okuda, T
    Mukainaka, T
    Tokuda, H
    Nishino, H
    Furukawa, H
    [J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (12): : 1668 - 1671