The application of polyhydroxyalkanoates as tissue engineering materials

被引:1141
作者
Chen, GQ [1 ]
Wu, Q
机构
[1] Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
[2] Shantou Univ, Multidisciplinary Res Ctr, Shantou 515063, Peoples R China
关键词
PHB; polyhydroxyalkanoates; tissue engineering; biodegradability; biocompatibility; hemocompatibility;
D O I
10.1016/j.biomaterials.2005.04.036
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Polyhydoxyalkanoates (PHA) are polyesters produced by microorganisms under unbalanced growth conditions. They are generally biodegradable and thermoprocessable, making them attractive as biomaterials for applications in both conventional medical devices and tissue engineering. Over the past years, PHA, particularly poly 3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV), poly 4-hydroxybutyrate (P4HB), copolymers of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx) and poly 3-hydroxyoctanoate (PHO) and its composites have been used to develop devices including sutures, repair devices. repair patches, slings, cardiovascular patches, orthopedic pins, adhesion barriers, stents, guided tissue repair/ regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, bone marrow scaffolds, and wound dressings. The changing PHA compositions also allow favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under specific physiological conditions. This paper reviews what have been achieved in the PHA tissue engineering area and concluded that the PHA prospective will look very bright in the near future. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:6565 / 6578
页数:14
相关论文
共 83 条
[31]   The healing process of palatal tissues after palatal surgery with and without implantation of membranes: an experimental study in dogs [J].
Leenstra, TS ;
Kuijpers-Jagtman, AM ;
Maltha, JC .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1998, 9 (05) :249-255
[32]   Biomaterial implants induce the inflammation marker CRP at the site of implantation [J].
Löbler, M ;
Sass, M ;
Kunze, C ;
Schmitz, KP ;
Hopt, UT .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 61 (01) :165-167
[33]   In vivo response to HA-polyhydroxybutyrate/polyhydroxyvalerate composite [J].
Luklinska, ZB ;
Schluckwerder, H .
JOURNAL OF MICROSCOPY, 2003, 211 :121-129
[34]   Morphology and ultrastructure of the interface between hydroxyapatite-polyhydroxybutyrate composite implant and bone [J].
Luklinska, ZB ;
Bonfield, W .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1997, 8 (06) :379-383
[35]   ENLARGEMENT OF THE RIGHT-VENTRICULAR OUTFLOW TRACT AND THE PULMONARY-ARTERY WITH A NEW BIODEGRADABLE PATCH IN TRANSANNULAR POSITION [J].
MALM, T ;
BOWALD, S ;
BYLOCK, A ;
BUSCH, C ;
SALDEEN, T .
EUROPEAN SURGICAL RESEARCH, 1994, 26 (05) :298-308
[36]  
Martin D.P., 2003, US Patent, Patent No. 403242
[37]  
Martin D. P., 1999, US Patent Appl., Patent No. 359086
[38]   Medical applications of poly-4-hydroxybutyrate: a strong flexible absorbable biomaterial [J].
Martin, DP ;
Williams, SF .
BIOCHEMICAL ENGINEERING JOURNAL, 2003, 16 (02) :97-105
[39]   ON THE BIODEGRADATION OF POLY-BETA-HYDROXYBUTYRATE (PHB) HOMOPOLYMER AND POLY-BETA-HYDROXYBUTYRATE-HYDROXYVALERATE COPOLYMERS [J].
MILLER, ND ;
WILLIAMS, DF .
BIOMATERIALS, 1987, 8 (02) :129-137
[40]   Effect of allogeneic Schwann cell transplantation on peripheral nerve regeneration [J].
Mosahebi, A ;
Fuller, P ;
Wiberg, M ;
Terenghi, G .
EXPERIMENTAL NEUROLOGY, 2002, 173 (02) :213-223