Transcription factories: quantitative studies of nanostructures in the mammalian nucleus

被引：37

作者：

Martin, S ^{[1
]}

Pombo, A ^{[1
]}

机构：

[1] Imperial Coll Sch Sci Technol & Med, Fac Med, MRC, Ctr Clin Sci, London W12 0NN, England

来源：

CHROMOSOME RESEARCH | 2003年 / 11卷 / 05期

基金：

英国医学研究理事会;

关键词：

nascent transcripts; nucleolus; RNA polymerase; transcription sites;

D O I：

10.1023/A:1024926710797

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription by the three nuclear RNA polymerases is carried out in transcription factories. This conclusion has been drawn from estimates of the total number of nascent transcripts or active polymerase molecules and the number of transcription sites within a cell. Here we summarise the variety of methods used to determine these parameters, discuss their associated problems and outline future prospects.

引用

页码：461 / 470

页数：10

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