Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins

被引:164
作者
Gu, XH [1 ]
Wan, XZ [1 ]
Jiang, B [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
关键词
D O I
10.1016/S0960-894X(99)00037-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The thiazole analogues of the marine bis(indole)alkaloid nortopsentins, 2,4-bis(3-indolyl)thiazoles, were synthesized using Hantzsch reaction between indole-3-thioamides and 3-(alpha-bromoacetyl)indoles as the key step, and these analogues showed potent cytotoxic activities against a variety of human cancer cell lines in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:569 / 572
页数:4
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