MAP kinase p38 and its relation to T cell anergy and suppressor function of regulatory T cells

被引：21

作者：

Adler, Henric S. ^{[1
]}

Steinbrink, Kerstin ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Dermatol, D-55131 Mainz, Germany

来源：

CELL CYCLE | 2008年 / 7卷 / 02期

关键词：

regulatory T cells; tolerogenic dendritic cells; cell cycle; anergy; p27(Kip1); MAP kinases; p38;

D O I：

10.4161/cc.7.2.5312

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Diverse regulatory T cell populations (Treg) are important for the control of self tolerance and immune homeostasis. These include naturally occurring CD4(+) CD25(+) Treg (nTreg) and induced Treg (iTreg). Tolerogenic dendritic cells, modulated by IL-10, are able to convert peripheral T cells into iTreg. These are anergic and characterized by a G(1) cell cycle arrest, dependent on elevated levels of the cdk inhibitor p27(Kip1). Novel data revealed a distinct pattern of MAP kinase activation in iTreg different from clonal T cell anergy, with enhanced activation of the p38-MAPKAP-K2/3 pathway. p38 is involved in cell cycle control and its activity is a prerequisite for the induction and maintenance of the anergic state in iTreg. Inhibition of p38 leads to down regulation of p27(Kip1), cell cycle progress and loss of regulatory T cell function. Here, we discuss these data in light of the role of p38 and p27(Kip1) in T cell activation, anergy induction and cell cycle control.

引用

页码：169 / 175

页数：7

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