Improved enzymatic galactose oleate ester synthesis in ionic liquids

被引：32

作者：

Abdulmalek, Emilia ^{[1
]}

Saupi, Hanim Salami Mohd ^{[1
]}

Tejo, Bimo A. ^{[1
]}

Basri, Mahiran ^{[1
]}

Salleh, Abu Bakar ^{[2
]}

Abd Rahman, Raja Noor Zaliha Raja ^{[2
]}

Rahman, Mohd Basyaruddin Abdul ^{[1
,3
]}

机构：

[1] Univ Putra Malaysia, Fac Sci, Dept Chem, Upm Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Upm Serdang 43400, Selangor, Malaysia

[3] Malaysia Genome Inst, Struct & Synthet Biol Res Ctr, Bangi 43600, Selangor, Malaysia

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2012年 / 76卷

关键词：

Galactose oleate ester; Ionic liquids; Oleic acid; Lipase; Sugar ester; LIPASE-CATALYZED SYNTHESIS; SUGAR ESTERS; OPTIMIZATION; MEDIA; DMSO;

D O I：

10.1016/j.molcatb.2011.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A fast and improved lipase-catalyzed synthesis of galactose oleate ester was performed in 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) ionic liquid with the addition of dimethylsulfoxide (DMSO) as a solubilizing agent and co-solvent; and Lipozyme RM IM (lipase from Rhizomucor miehei immobilized on macroporous anion exchange resin) as the biocatalyst. Different reaction parameters (type of solvent, type of enzyme, amount of enzyme, reaction time, temperature, stirring rate and substrate molar ratio) were studied. A high conversion (87%) was obtained after only 2 h at optimal synthesis conditions (1:20 DMSO:[Bmim][BF4] ratio with 2% (w/w) Lipozyme RM IM, temperature 60 degrees C, stirring rate of 300 rpm and a molar ratio of galactose to oleic acid of 1:3). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：37 / 43

页数：7

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