Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L.

被引：40

作者：

Kwon, DH

Kwon, HY

Kim, HJ

Chang, EJ

Kim, MB

Yoon, SK

Song, EY

Yoon, DY

Lee, YH

Choi, IS

Choi, YK

机构：

[1] Korea Res Inst Biosci & Biotechnol, Cell Biol Lab, Taejon 305333, South Korea

[2] Chungnam Natl Univ, Dept Food Technol, Taejon 305764, South Korea

[3] Biokorea Co, Seoul 135280, South Korea

[4] Kyongnam Agr Res & Extens Serv, Jinju 660985, South Korea

[5] Catholic Univ Korea, Coll Med, Seoul 137040, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 04期

关键词：

genus Agrimonia; antiviral activity; aqueous extracts; HBsAg; seasonal variation;

D O I：

10.1002/ptr.1689

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Inhibition of HBsAg release against hepatitis B virus (HBV) was investigated in an aqueous extract prepared from the aerial parts (stems and leaves) of Agrimonia eupatoria. The inhibitory effect on HBsAg secretion was footed using aqueous extracts of Agrimonia eupatoria at four different temperatures (37 degrees C 45 degrees C, 55 degrees C and 60 degrees C), and the extract prepared at 60 degrees C was found to have the greatest effect. The inhibitory activity of Agrimonia eupatoria extracts on HBsAg secretion varied over the growing season and was the highest at mid-July. This inhibitory activity was also shown with the aqueous extracts of two other species of the genus Agrimonia: A. pilosa and A. coreana pilosella. These results suggest that some plants of the genus Agrimonia contain potential antiviral activity against HBV. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：355 / 358

页数：4

共 19 条

[1]

Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study [J].