The diversity of endothelial cells: a challenge for therapeutic angiogenesis

被引:46
作者
Conway, EM [1 ]
Carmeliet, P [1 ]
机构
[1] Univ Leuven VIB, Gasthuisberg O&N, Ctr Transgene Technol & Gene Therapy, B-3000 Leuven, Belgium
关键词
D O I
10.1186/gb-2004-5-2-207
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Vascular endothelia comprise a diverse population of cells that specialize in response to genetic programs and environmental cues to take on distinct roles in different vessels, tissues, and organs, and in response to pathophysiological stresses. Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases.
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页数:5
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共 30 条
[11]   Diverse origin and function of cells with endothelial phenotype obtained from adult human blood [J].
Gulati, R ;
Jevremovic, D ;
Peterson, TE ;
Chatterjee, S ;
Shah, V ;
Vile, RG ;
Simari, RD .
CIRCULATION RESEARCH, 2003, 93 (11) :1023-1025
[12]   Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells [J].
Hirakawa, S ;
Hong, YK ;
Harvey, N ;
Schacht, V ;
Matsuda, K ;
Libermann, T ;
Detmar, M .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (02) :575-586
[13]   Molecular regulation of vessel maturation [J].
Jain, RK .
NATURE MEDICINE, 2003, 9 (06) :685-693
[14]   Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells [J].
Lang, I ;
Pabst, MA ;
Hiden, U ;
Blaschitz, A ;
Dohr, G ;
Hahn, T ;
Desoye, G .
EUROPEAN JOURNAL OF CELL BIOLOGY, 2003, 82 (04) :163-173
[15]  
Lawson ND, 2001, DEVELOPMENT, V128, P3675
[16]   EG-VEGF and Bv8: A novel family of tissue-selective mediators of angiogenesis, phenotype, endothelial and function [J].
LeCouter, J ;
Ferrara, N .
TRENDS IN CARDIOVASCULAR MEDICINE, 2003, 13 (07) :276-282
[17]   SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier [J].
Lee, SW ;
Kim, WJ ;
Choi, YK ;
Song, HS ;
Son, MJ ;
Gelman, IH ;
Kim, YJ ;
Kim, KW .
NATURE MEDICINE, 2003, 9 (07) :900-906
[18]   Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment [J].
Lim, YC ;
Garcia-Cardena, G ;
Allport, JR ;
Zervoglos, M ;
Connolly, AJ ;
Gimbrone, MA ;
Luscinskas, FW .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (05) :1591-1601
[19]   Lymphangiogenic growth factors, receptors and therapies [J].
Lohela, M ;
Saaristo, A ;
Veikkola, T ;
Alitalo, K .
THROMBOSIS AND HAEMOSTASIS, 2003, 90 (02) :167-184
[20]  
Moyon D, 2001, DEVELOPMENT, V128, P3359